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3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices.

Janko Kajtez1, Sebastian Buchmann2, Shashank Vasudevan2

  • 1Department of Experimental Medical Sciences Wallenberg Neuroscience Center Division of Neurobiology and Lund Stem Cell Center BMC A11 Lund University Lund S-22184 Sweden.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 25, 2020
PubMed
Summary
This summary is machine-generated.

A new hybrid manufacturing method simplifies the creation of advanced microfluidic devices for neuroscience. This approach supports long-term culture of human neurons and astrocytes, enabling complex in vitro models.

Keywords:
3D printingcompartmentalized devicesfast prototypinghuman neural stem cellsneurite guidancenigrostriatal pathwaysoft lithography

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Compartmentalized microfluidic platforms are crucial for neuroscience research.
  • Current fabrication methods limit device complexity and require manual postprocessing.

Purpose of the Study:

  • To present a hybrid additive manufacturing approach for fabricating open-well compartmentalized neural devices.
  • To enhance device design freedom, eliminate manual postprocessing, and improve biocompatibility.
  • To enable long-term maintenance of human stem-cell derived neurons and astrocytes.

Main Methods:

  • Utilizing a hybrid additive manufacturing technique for microfluidic device fabrication.
  • Implementing multimaterial integration for tailored device architecture.
  • Employing fast-prototyping capabilities at micro and macro scales.

Main Results:

  • Successful fabrication of intricate device architectures with high-aspect ratio features.
  • Demonstrated long-term maintenance (≥40 days) of healthy human stem-cell derived neurons and astrocytes.
  • Created a proof-of-principle human in vitro model of the nigrostriatal pathway.

Conclusions:

  • The hybrid additive manufacturing method offers a simplified and versatile approach to creating advanced microfluidic neural devices.
  • This technology facilitates the development of sophisticated in vitro models for biological research, including neuroscience.
  • The method opens new avenues for novel materials and architectures in microfluidic systems for diverse applications.