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Related Experiment Videos

Regional hyperthermia for deep-seated malignancies using the BSD annular array.

D S Shimm1, T C Cetas, J R Oleson

  • 1Arizona Cancer Center, Tucson.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|March 1, 1988
PubMed
Summary
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The BSD-1000 Annular Phased Array showed limited efficacy in treating various cancers, with toxicity often preventing optimal hyperthermia. Future advancements in technology and combination therapies are needed for improved clinical outcomes.

Area of Science:

  • Oncology
  • Medical Physics
  • Biomedical Engineering

Background:

  • Hyperthermia therapy aims to increase tumor temperature to enhance treatment efficacy.
  • The BSD-1000 Annular Phased Array was an early technology used for clinical hyperthermia.
  • Previous studies explored its application in pelvic, abdominal, extremity, and thoracic tumors.

Purpose of the Study:

  • To evaluate the clinical outcomes and toxicity of hyperthermia treatment using the BSD-1000 Annular Phased Array.
  • To assess the feasibility of achieving therapeutic tumor temperatures with this device.
  • To identify limitations and suggest future directions for improving hyperthermia treatment.

Main Methods:

  • Retrospective analysis of 44 patients treated between April 1983 and December 1986.

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  • Treatment involved the BSD-1000 Annular Phased Array, often combined with radiation therapy.
  • Patient data included tumor site, volume, treatment temperature, toxicity, and response.

    • Main Results:

    • Most patients experienced toxicity, leading to treatment interruptions or termination.
    • Achieving tumor temperatures >= 42°C was challenging due to toxicity.
    • Six complete and five partial responses were observed, with better outcomes in pelvic tumors.

    Conclusions:

    • The BSD-1000 Annular Phased Array demonstrated significant toxicity, limiting its effectiveness in achieving therapeutic hyperthermia.
    • Improvements in technology, such as steerable phased arrays or focused ultrasound, are needed.
    • Combination therapies with drugs or biological agents may enhance clinical hyperthermia outcomes.