Related Experiment Video
Updated: Dec 11, 2025
08:35
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
2.9K
Silent myocardial dysfunction in vitamin D deficiency.
Pelin Karaca Ozer1, Samim Emet1, Ekrem Bilal Karaayvaz1
1Department of Cardiology, Medical Faculty, Istanbul University, Istanbul, Turkey.
Archives of Medical Sciences. Atherosclerotic Diseases
|August 25, 2020
Summary
Vitamin D deficiency is linked to impaired heart function, specifically reduced global longitudinal strain (GLS) in patients with or without diabetes. This suggests Vitamin D deficiency may cause subclinical myocardial dysfunction.
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is a prevalent condition with emerging links to cardiovascular disease.
- Subclinical myocardial dysfunction is a key indicator of early heart disease.
Purpose of the Study:
- To investigate the impact of Vitamin D deficiency on subclinical left ventricular (LV) function.
- To assess these effects in both diabetic and non-diabetic patients without significant coronary artery disease.
Main Methods:
- 140 patients (80 diabetic, 60 non-diabetic) with stable ischemic heart disease but no significant coronary artery disease were studied.
- 25(OH)D3 levels were measured; deficiency was defined as <20 ng/dl.
- Tissue Doppler echocardiography and 2D speckle tracking strain echocardiography (2D STE) assessed LV diastolic function and myocardial deformation.
Main Results:
- Patients with Vitamin D deficiency showed significantly impaired LV global longitudinal strain (GLS) (p < 0.001) and GLSR (p = 0.003).
- GLS was negatively associated with 25(OH)D3 in deficient patients (r = -0.52623, p < 0.001).
- Conversely, GLS was positively associated with 25(OH)D3 in patients with normal Vitamin D levels (r = 0.28, p = 0.048).
Conclusions:
- Vitamin D deficiency is associated with impaired myocardial GLS, indicating subclinical myocardial dysfunction.
- This dysfunction occurs in patients with or without diabetes mellitus and no significant coronary artery disease.
More Related Videos
Related Concept Videos
01:30Cardiomyopathy II: Dilated Cardiomyopathy
288
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
288
01:30Coronary Artery Disease III: Clinical Manifestations
217
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
217
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
312
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
312
01:26Coronary Artery Disease II: Pathophysiology
253
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
253
01:26Imbalances in Cardiac Output
2.0K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.0K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
242
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
242