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Silent myocardial dysfunction in vitamin D deficiency.

Pelin Karaca Ozer1, Samim Emet1, Ekrem Bilal Karaayvaz1

  • 1Department of Cardiology, Medical Faculty, Istanbul University, Istanbul, Turkey.

Archives of Medical Sciences. Atherosclerotic Diseases
|August 25, 2020
PubMed
Summary

Vitamin D deficiency is linked to impaired heart function, specifically reduced global longitudinal strain (GLS) in patients with or without diabetes. This suggests Vitamin D deficiency may cause subclinical myocardial dysfunction.

Keywords:
coronary artery diseasemyocardial deformationstrainstrain ratevitamin D

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Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is a prevalent condition with emerging links to cardiovascular disease.
  • Subclinical myocardial dysfunction is a key indicator of early heart disease.

Purpose of the Study:

  • To investigate the impact of Vitamin D deficiency on subclinical left ventricular (LV) function.
  • To assess these effects in both diabetic and non-diabetic patients without significant coronary artery disease.

Main Methods:

  • 140 patients (80 diabetic, 60 non-diabetic) with stable ischemic heart disease but no significant coronary artery disease were studied.
  • 25(OH)D3 levels were measured; deficiency was defined as <20 ng/dl.
  • Tissue Doppler echocardiography and 2D speckle tracking strain echocardiography (2D STE) assessed LV diastolic function and myocardial deformation.

Main Results:

  • Patients with Vitamin D deficiency showed significantly impaired LV global longitudinal strain (GLS) (p < 0.001) and GLSR (p = 0.003).
  • GLS was negatively associated with 25(OH)D3 in deficient patients (r = -0.52623, p < 0.001).
  • Conversely, GLS was positively associated with 25(OH)D3 in patients with normal Vitamin D levels (r = 0.28, p = 0.048).

Conclusions:

  • Vitamin D deficiency is associated with impaired myocardial GLS, indicating subclinical myocardial dysfunction.
  • This dysfunction occurs in patients with or without diabetes mellitus and no significant coronary artery disease.