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Quercetin and curcumin effects in experimental pleural inflammation
Cristina Bidian1, Daniela-Rodica Mitrea1, Olivia Gabriela Vasile1
1Physiology Department, Functional Biosciences Division, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Medicine and Pharmacy Reports
|August 25, 2020
Summary
Quercetin and curcumin show antioxidant effects against carrageenan-induced pleural inflammation in rats. Curcumin is more effective in serum, while quercetin offers temporary lung protection.
Area of Science:
- Pulmonary pathology
- Oxidative stress
- Inflammation
Background:
- Oxidative stress, an imbalance between pro-oxidants and antioxidants, contributes to inflammatory diseases.
- Quercetin and curcumin are natural compounds with significant antioxidant and anti-inflammatory properties.
Purpose of the Study:
- To evaluate the antioxidant effects of quercetin and curcumin.
- To assess their impact on carrageenan-induced pleural inflammation in an experimental rat model.
Main Methods:
- Adult male rats were divided into eight groups, including control, carrageenan-only, and groups treated with curcumin or quercetin alongside carrageenan.
- Blood and lung samples were collected at 4 and 24 hours post-carrageenan injection.
Main Results:
- Both quercetin and curcumin administration significantly reduced oxidative stress (malondialdehyde) and increased antioxidant levels (ceruloplasmin, glutathione) in serum.
- Quercetin demonstrated a significant reduction in lung redox imbalance at 4 hours, but this effect was not sustained at 24 hours.
Conclusions:
- Curcumin exhibited stronger antioxidant effects in the serum compared to quercetin.
- Quercetin provided superior, albeit temporary, beneficial effects on lung tissue during acute inflammation.
