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Updated: Dec 11, 2025

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine
Published on: July 28, 2023
Embryonal Carcinoma and Glioblastoma Cell Lines Derived from Monkey Induced Pluripotent Stem Cells
Hirohito Ishigaki1, Yasushi Itoh2
1Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan. ihirona2@gmail.com.
Abstract:
Induced pluripotent stem cells (iPSCs) are useful for the development of therapies in regenerative medicine, analysis of pathogenesis, and exploration of candidate drugs. We developed an alternative usage of iPSCs of which the MHC haplotype is matched to transplantable recipients in a cynomolgus macaque model. We established two cancer cell lines, embryonal carcinoma, and glioblastoma cell lines from cynomolgus monkey iPSCs. Here, we describe a method to induce the cancer cell lines including a technique for culture of the monkey iPSCs on feeder cells and the induction of hematopoietic stem cells and neural progenitor cells from monkey iPSCs.
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