Target specific mining of COVID-19 scholarly articles using one-class approach

Sanjay Kumar Sonbhadra1, Sonali Agarwal1, P Nagabhushan1

  • 1IIIT Allahabad, Prayagraj, U.P. India 211015.

Chaos, Solitons, and Fractals
|August 25, 2020
PubMed

Insights

Machine learning, specifically k-means clustering and one-class support vector machines (OCSVMs), effectively categorizes COVID-19 research. This approach aids researchers in navigating the vast literature on coronavirus disease 2019 (COVID-19) prevention and treatment.

Area of Science:

  • Computational Biology
  • Data Science
  • Infectious Disease Research

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to a surge in research publications.
  • Manually extracting relevant information from the extensive body of COVID-19 literature is impractical.
  • Efficiently identifying research trends and activities is crucial for advancing prevention and treatment strategies.

Purpose of the Study:

  • To develop and validate a machine learning approach for analyzing and categorizing COVID-19 research articles.
  • To assist the research community in navigating the vast scientific literature on coronavirus disease 2019 (COVID-19).
  • To identify trends and activities within COVID-19 research for future exploration of prevention and treatment techniques.

Main Methods:

  • Utilized the COVID-19 Open Research Dataset (CORD-19) for experimental analysis.
  • Employed clustering techniques, specifically k-means, to group similar research articles.
  • Applied parallel one-class support vector machines (OCSVMs) for task assignment and classification of article clusters.

Main Results:

  • The combination of k-means clustering followed by parallel OCSVMs demonstrated superior performance in categorizing research articles.
  • The proposed method proved effective in both original and reduced feature spaces, validating its robustness.
  • The approach successfully mined target-class guided information, revealing patterns in COVID-19 research.

Conclusions:

  • The machine learning methodology, particularly k-means clustering with parallel OCSVMs, is an effective tool for analyzing large-scale research datasets like CORD-19.
  • This approach facilitates efficient exploration of scientific literature, aiding researchers in identifying key trends and knowledge gaps in COVID-19 research.
  • The findings support the use of advanced data analytics for accelerating scientific discovery in response to global health crises.

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.7K
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.3K
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.4K
Chi-square Analysis02:46

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
42.4K