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Updated: Dec 11, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
COVID-19 interventions in some European countries induced bifurcations stabilizing low death states against high
1Dept of Psychology and Dept of Physics, University of Connecticut, Storrs, CT, 06269, USA.
Abstract:
Taking a dynamical systems perspective, COVID-19 infections are assumed to spread out in a human population via an instability. Conversely, government interventions to reduce the spread of the disease and the number of fatalities may induce a bifurcation that stabilizes a desirable state with low numbers of COVID-19 cases and associated deaths. The key characteristic feature of an infection dynamical system in this context is the eigenvalue that determines the stability of the states under consideration and is known in synergetics as the order parameter eigenvalue. Using a SEIR-like infection disease model, the relevant order parameter and its eigenvalue are determined. A three stage methodology is proposed to track and estimate the eigenvalue through time. The method is applied to COVID-19 infection data reported from 20 European countries during the period of January 1, 2020 to June 15. It is shown that in 15 out of the 20 countries the eigenvalue switched its sign suggesting that during the reporting period an intervention bifurcation took place that stabilized the desirable low death state. It is shown that the eigenvalue analysis also allows for a ranking of countries by the degree of the stability of the infection-free state. For the investigated countries, Ireland was found to exhibit the most stable infection-free state. Finally, a six point classification scheme is suggested with groups 5 and 6 including countries that failed to stabilize the desirable infection-free low death state. In doing so, tools for assessing the effectiveness of government interventions are provided that are at the heart of bifurcation theory, in general, and synergetics, in particular.
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