Related Experiment Video

Updated: Dec 11, 2025

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
07:21

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

22.0K

Predisposition or Protection?: COVID-19 in a Patient on LVAD Support With HIV/AIDS

Kiran Mahmood1, Eman R Rashed1, Estefania Oliveros1

  • 1Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

JACC. Case Reports
|August 25, 2020
PubMed

Insights

Researchers explored coronavirus disease-2019 (COVID-19) treatment in a unique patient with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). This case study details the patient's recovery from COVID-19, offering insights into potential therapeutic effects.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • The search for effective coronavirus disease-2019 (COVID-19) therapies is ongoing.
  • Patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) present a unique cohort for studying COVID-19 clinical courses.
  • Antiretroviral therapy (ART) in HIV/AIDS patients may influence COVID-19 outcomes.

Observation:

  • A case report of a patient with HIV/AIDS on left ventricular assist device (LVAD) support is presented.
  • The patient was hospitalized with COVID-19.
  • The patient successfully recovered from COVID-19.

Findings:

  • This case highlights the recovery of an immunocompromised patient with significant comorbidities from COVID-19.
  • The clinical course suggests that existing antiretroviral therapies might play a role in managing COVID-19 in HIV/AIDS patients.

Implications:

  • Further research into the interaction between antiretroviral therapy and COVID-19 is warranted.
  • This case contributes to understanding COVID-19 in vulnerable populations.
  • Insights may guide the development of targeted COVID-19 treatment strategies for immunocompromised individuals.

Keywords:
AIDS, acquired immunodeficiency syndromeART, antiretroviral therapyCOVID-19, coronavirus disease-2019HIV, human immunodeficiency virusHIV/AIDSIL, interleukinLVADLVAD, left ventricular assist deviceSARS, severe acute respiratory syndromeSARS-CoV-2, severe acute respiratory syndrome-coronavirus-2antiretroviral therapycoronavirus diseasemechanical circulatory support

More Related Videos

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

2.2K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.7K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.8K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
625
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
48.8K
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.7K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
696
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
509