Related Experiment Video

Updated: Dec 11, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K

SARS-CoV-2 Fulminant Myocarditis

Jérôme Garot1, Julien Amour2, Théo Pezel1

  • 1Cardiovascular Magnetic Resonance Laboratory, Institut Cardiovasculaire Paris Sud, Hôpital Privé Jacques Cartier, Ramsay Santé, Massy, France.

JACC. Case Reports
|August 25, 2020
PubMed

Insights

Fulminant myocarditis occurred alongside severe COVID-19 pneumonia in an 18-year-old male. Cardiac magnetic resonance confirmed the diagnosis, highlighting potential diagnostic and pathogenic insights.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Fulminant myocarditis is a rare but severe inflammation of the heart muscle.
  • COVID-19 pneumonia can present with a wide range of cardiac complications.
  • Young, otherwise healthy individuals can be susceptible to severe COVID-19 manifestations.

Observation:

  • An 18-year-old male with no prior medical history presented with severe COVID-19 pneumonia.
  • The patient concurrently developed fulminant myocarditis.
  • Serial cardiac magnetic resonance imaging was utilized for diagnosis and monitoring.

Findings:

  • The case demonstrates a direct correlation between severe COVID-19 pneumonia and the development of fulminant myocarditis.
  • Cardiac magnetic resonance imaging proved effective in diagnosing and characterizing the myocarditis.
  • The patient's presentation suggests a potential pathogenic link between SARS-CoV-2 infection and acute cardiac inflammation.

Implications:

  • This case highlights the importance of considering myocarditis in young patients with severe COVID-19.
  • Serial cardiac imaging is crucial for monitoring cardiac involvement and guiding treatment.
  • Understanding this association may offer insights into the pathogenesis of viral myocarditis and COVID-19 complications.

Keywords:
COVID-19, coronavirus disease-2019EF, ejection fractionEGE, early gadolinium enhancementLGE, late gadolinium enhancementLV, left ventricleLVEF, left ventricular ejection fractionSARS-CoV-19, severe acute respiratory syndrome-coronavirus-2019cardiac magnetic resonancecoronavirus disease 2019myocarditis

More Related Videos

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

9.6K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
230
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
151
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
283
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
95
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
308
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
475