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Masked hypertension is related to alteration of myocardial arrhythmia Parameters

Ömer Çağlar Yılmaz1, Selçuk Ozkan2, Bunyamin Yavuz2

  • 1Private Ankara Etimet Hospital , Private Cardiology Clinic , Ankara, Turkey.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|August 25, 2020
PubMed

Insights

Masked hypertension significantly worsens heart rate variability (HRV) and QT dynamicity, increasing arrhythmia risk. This study highlights the importance of monitoring these parameters in patients with masked hypertension.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Hypertension Studies

Background:

  • Arterial hypertension is linked to autonomic imbalance and impaired myocardial repolarization, elevating arrhythmia risk.
  • Masked hypertension, often undiagnosed, presents unique challenges in cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the impact of masked hypertension on QT interval dynamicity.
  • To evaluate alterations in heart rate variability (HRV) in patients with masked hypertension.

Main Methods:

  • Compared 108 masked hypertension patients with 102 controls using 24-hour Holter monitoring.
  • Analyzed heart rate variability (HRV) and QT dynamicity parameters using CONTEC holter software.
  • Included comprehensive medical history, lab tests, and echocardiography for all participants.

Main Results:

  • Masked hypertension patients exhibited significantly reduced HRV indices (SDNN, RMSSD, PNN50, LFnu, HFnu) and an increased LF/HF ratio.
  • QT/RR slopes for QT end and QT apex were significantly steeper in the masked hypertension group.
  • No significant age-gender differences were observed between groups; non-sustained VT was rare.

Conclusions:

  • Masked hypertension is associated with significant deterioration in HRV and QT dynamicity.
  • These findings suggest a heightened risk of arrhythmias in individuals with masked hypertension.
  • This study provides novel insights into the cardiovascular implications of masked hypertension.
Abstract

Keywords:
Hearth rate variabilityQT dynamicityhypertensionmasked hypertensionsympathetic system

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