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Risk factors for frontal fibrosing alopecia: A case-control study in a multiracial population
Paulo Müller Ramos1, Alessandra Anzai2, Bruna Duque-Estrada3
1Universidade Estadual Paulista, Botucatu, Brazil.
Journal of the American Academy of Dermatology
|August 25, 2020
Summary
Frontal fibrosing alopecia (FFA) may be triggered by external factors like hair straightening treatments and certain skincare products. Smoking and clarifying shampoos appear to reduce the risk of developing FFA.
Area of Science:
- Dermatology
- Epidemiology
Background:
- Frontal fibrosing alopecia (FFA) is a progressive scarring hair loss condition with increasing global prevalence.
- The etiology of FFA remains largely unknown.
Purpose of the Study:
- To investigate potential demographic, environmental, and lifestyle factors associated with FFA.
- To explore these associations within a diverse Brazilian population.
Main Methods:
- A multicenter case-control study involving 902 participants (451 with FFA, 451 controls).
- Data collected via a comprehensive questionnaire covering demographics, exposures, diet, and personal care habits.
Main Results:
- FFA was significantly associated with hair straightening using formalin, facial soaps, and moisturizers.
- Thyroid disorders and rosacea were also linked to FFA.
- Smoking and use of clarifying shampoos showed a protective association against FFA.
Conclusions:
- Findings suggest exogenous agents, such as those in hair and skincare products, may play a role in triggering FFA.
- Further research is needed to confirm these associations and elucidate the underlying mechanisms.
