β-blockers in the environment: Distribution, transformation, and ecotoxicity
Ming Yi1, Qi Sheng1, Qian Sui2
1Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
Beta-blockers, used for heart conditions, are found globally in water. Their environmental fate and toxicity require further study, with propranolol showing the highest aquatic toxicity.
Area of Science:
- Environmental chemistry
- Ecotoxicology
- Pharmaceuticals in the environment
Background:
- Beta-blockers are crucial cardiovascular drugs with widespread environmental presence.
- Concerns exist regarding their chronic toxicity to aquatic ecosystems.
- Comprehensive studies on environmental distribution, fate, and toxicity are necessary.
Purpose of the Study:
- To review current knowledge on beta-blocker sources, distribution, analysis, transformation, and toxicity.
- To identify knowledge gaps and research priorities.
Main Methods:
- Literature review of environmental studies on beta-blockers.
- Analysis of data on detection, removal efficiencies, and toxicity.
Main Results:
- Twelve beta-blockers detected globally with significant variations.
- Wastewater treatment plants remove 0-99% of beta-blockers, primarily via secondary processes.
- Advanced oxidation processes offer more efficient but potentially more toxic transformation products.
- Propranolol, particularly (S)-enantiomer, shows the highest aquatic toxicity.
Conclusions:
- Beta-blockers are persistent environmental contaminants requiring monitoring.
- Advanced treatment methods need careful evaluation due to potentially toxic byproducts.
- Further research on detection, removal, and toxicity is essential for risk assessment and management.
More Related Videos
05:46Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation
Published on: August 1, 2018
08:22Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
Published on: December 22, 2023
Related Concept Videos
Antihypertensive Drugs: Types of β-Blockers
Adrenergic Antagonists: Chemistry and Classification of β-Receptor Blockers
Antihypertensive Drugs: Action of β1 Blockers
Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
Adrenergic Antagonists: ɑ and β-Receptor Blockers
Drug Biotransformation: Overview
