Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.5K
Cancer Vaccines01:30

Cancer Vaccines

857
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
857
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.5K
Cancer Therapies02:49

Cancer Therapies

9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.7K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indigenous knowledge and modern science: a comprehensive review of phytochemicals in <i>Panax ginseng</i> flower for nutritional and health applications.

Frontiers in nutrition·2026
Same author

NSUN2/m5C/TPI1 axis promotes glycolysis and immune evasion in breast cancer.

Journal of translational medicine·2026
Same author

Efficacy and Safety of Oral NEPA Versus Fosaprepitant Plus Palonosetron for Preventing Chemotherapy-Induced Nausea and Vomiting in Patients with Nasopharyngeal Carcinoma: A Propensity-Score-Matched Retrospective Study.

Cancers·2026
Same author

Photoinduced Radical Alkylation of Cyclic Aldimines with Unactivated C(sp<sup>3</sup>)-H Alcohols Enabled by Alcohol-Directed 1,5-Hydrogen Atom Transfer.

The Journal of organic chemistry·2026
Same author

A mitochondria-targeted salvianic acid a delivery system for anti-inflammatory treatment of rheumatoid arthritis.

International journal of pharmaceutics·2026
Same author

Food consumption behaviour and self-perceived nutrition knowledge: a case study of students with limited formal nutrition education in pre-university schooling.

Public health nutrition·2026

Related Experiment Video

Updated: Dec 11, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.8K

Cancer neoantigen: Boosting immunotherapy.

Peijia Xu1, Haiqing Luo2, Ying Kong3

  • 1Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, 524023, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, 524023, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 25, 2020
PubMed
Summary

Tumor neoantigens are highly immunogenic targets for cancer vaccines, particularly for melanoma. This review covers neoantigen identification and personalized vaccines for metastatic cancers.

Keywords:
ImmunotherapyMelanomaNeoantigenPersonalized vaccineTumor mutational burden

More Related Videos

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

1.5K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.6K

Related Experiment Videos

Last Updated: Dec 11, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.8K
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

1.5K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.6K

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Tumor neoantigens possess high immunogenicity, making them promising targets for cancer immunotherapy.
  • Current immunotherapies often lack specificity and cause significant side effects.
  • Targeting highly immunogenic tumor antigens is crucial for effective immune attack against tumors.

Purpose of the Study:

  • To review the identification and influencing factors of tumor neoantigens.
  • To discuss the application of personalized neoantigen vaccines in treating metastatic cancers, with a focus on melanoma.

Main Methods:

  • Literature review on neoantigen identification techniques.
  • Analysis of factors influencing neoantigen immunogenicity.
  • Examination of clinical trial data for personalized neoantigen vaccines in solid tumors.

Main Results:

  • Neoantigen identification is key to developing effective cancer immunotherapies.
  • Personalized neoantigen vaccines show promise in clinical trials, especially for melanoma.
  • Factors influencing neoantigen presentation and recognition are critical for vaccine efficacy.

Conclusions:

  • Neoantigen-targeted vaccines represent a significant advancement in cancer immunotherapy.
  • Personalized vaccine strategies offer a more specific and potentially less toxic treatment approach for metastatic melanoma and other solid tumors.
  • Further research into neoantigen characteristics and vaccine optimization is warranted.