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[Acute renal failure during COVID-19 epidemic]
Lucie Darriverre1, Fabienne Fieux1, Christophe de la Jonquière1
1Service d'anesthésie réanimation, hôpital Saint-Antoine, AP-HP, Paris, France.
Le Praticien En Anesthesie Reanimation
|August 25, 2020
Summary
COVID-19 patients in intensive care units frequently develop acute kidney injury. This kidney damage stems from reduced blood flow, inflammation, and direct viral effects, complicating treatment.
Area of Science:
- Nephrology
- Virology
- Critical Care Medicine
Context:
- Acute respiratory distress syndrome (ARDS) is a severe COVID-19 complication.
- Renal impairment is prevalent in hospitalized COVID-19 patients.
- Estimating the global prevalence of SARS-CoV-2 kidney injury remains challenging.
Purpose:
- To outline the mechanisms of kidney injury in COVID-19 patients.
- To highlight the challenges in managing acute renal failure in this population.
Summary:
- COVID-19-associated acute kidney injury involves decreased renal perfusion due to mechanical ventilation and sepsis.
- Direct viral toxicity targets proximal tubular cells and podocytes via ACE 2 and TMPRSS proteases.
- Over 20% of intensive care unit COVID-19 patients need extra renal replacement therapy (ERT) for acute renal failure.
- Hypercoagulable state in COVID-19 patients complicates ERT due to filter thrombosis.
Impact:
- Understanding these mechanisms is crucial for managing COVID-19 patients with kidney complications.
- Improved management strategies are needed to address acute renal failure and hypercoagulability.
- This research informs clinical practice for intensive care units managing severe COVID-19 cases.
Keywords:
Acute kidney injuryAcute respiratory distress syndromeCOVID-19 pandemicRenal replacement therapyMore Related Videos
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