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Related Experiment Video

Updated: Dec 11, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
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Scalable COVID-19 Detection Enabled by Lab-on-Chip Biosensors.

Carly Tymm1, Junhu Zhou1, Amogha Tadimety1

  • 1Thayer School of Engineering, Dartmouth College, Hanover, NH USA.

Cellular and Molecular Bioengineering
|August 25, 2020
PubMed
Summary

Lab-on-chip biosensors offer rapid, low-cost COVID-19 diagnosis at the point-of-care. These technologies are crucial for scaling up testing capacity globally to meet demand for widespread SARS-CoV-2 detection.

Keywords:
BiosensorCOVID-19CoronavirusDiagnosticLab-on-chip

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Infectious Disease Diagnostics

Background:

  • The COVID-19 pandemic necessitates rapid, accurate, point-of-care diagnostic solutions.
  • Current global testing capacity is insufficient to meet projected demands for SARS-CoV-2 detection.
  • The need for scalable diagnostic tools is critical for public health responses and reopening strategies.

Purpose of the Study:

  • To review the development of lab-on-chip biosensing platforms for COVID-19 diagnosis.
  • To highlight the advantages of lab-on-chip technologies for pandemic response.
  • To serve as a resource for future innovations in COVID-19 detection assays.

Main Methods:

  • Review of magnetic, colorimetric, plasmonic, electrical, and lateral flow lab-on-chip technologies.
  • Focus on rapid, point-of-care devices for SARS-CoV-2 detection.
  • Evaluation of technologies as alternatives to RT-PCR.

Main Results:

  • Lab-on-chip technologies offer low-cost, rapid sample-to-answer processing.
  • These platforms can be easily integrated into various healthcare settings.
  • Various lab-on-chip approaches show promise for detecting SARS-CoV-2 and other viruses.

Conclusions:

  • Lab-on-chip biosensors represent a promising alternative to traditional RT-PCR for COVID-19 diagnostics.
  • These technologies are suitable for large-scale deployment and point-of-care applications.
  • Further development of these assays can significantly enhance global diagnostic capabilities.