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[Delayed type hypersensitivity and Immunity (author's transl)].

H Hahn, S H Kaufmann

    Immunitat Und Infektion
    |June 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Delayed type hypersensitivity is a T-cell immune response. This T-cell-mediated phenomenon involves mononuclear cells and lymphocytes, crucial for local immunity against pathogens and foreign tissues.

    Area of Science:

    • Immunology
    • Cellular Biology

    Context:

    • Delayed type hypersensitivity (DTH) is a critical T-cell-mediated immune response.
    • Characterized by a 24-72 hour development period post-antigen challenge.
    • Involves perivascular mononuclear cell infiltration and is transferable via lymphocytes.

    Purpose:

    • To elucidate the cellular mechanisms underlying delayed type hypersensitivity.
    • To highlight the role of T-cells and mononuclear phagocytes in DTH.
    • To explore the implications of DTH in various pathological conditions.

    Summary:

    • Delayed type hypersensitivity (DTH) is a T-cell-dependent immune reaction.
    • It involves specific T-cells and mononuclear phagocytes working collaboratively.
    • This interaction generates local immunity to combat pathogens or foreign tissue.

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    Impact:

    • Demonstrates DTH as an indicator of specific T-cell and phagocyte activity.
    • Underscores the importance of DTH in host defense against intracellular bacteria, viruses, tumors, and transplant rejection.
    • Provides insights into local immunity and the elimination of noxious agents.