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Updated: Dec 11, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Current Applications for Nuclear Medicine Imaging in Pulmonary Disease
Joanna E Kusmirek1, Josiah D Magnusson1, Scott B Perlman1
1Radiology Department, Section of Nuclear Medicine and Molecular Imaging, Madison School of Medicine and Public Health, University of Wisconsin, 600 Highland Ave, Madison, WI 53792 USA.
Nuclear medicine and molecular imaging offer advanced diagnostic and therapeutic options for pulmonary diseases. These techniques, including SPECT and PET scans, are crucial for improving patient care and exploring future applications.
Area of Science:
- Nuclear Medicine
- Molecular Imaging
- Radiopharmaceuticals
Background:
- Nuclear medicine utilizes radioactive tracers for diagnostic and therapeutic purposes.
- Molecular imaging allows for visualization of biological processes at the cellular and molecular level.
- Pulmonary diseases present complex diagnostic challenges requiring advanced imaging modalities.
Purpose of the Study:
- To review current and emerging nuclear medicine and molecular imaging procedures for pulmonary diseases.
- To highlight the role of these imaging techniques in enhancing patient care.
- To discuss future directions in nuclear medicine, including targeted tracers and theranostics.
Main Methods:
- Review of established and novel nuclear medicine imaging modalities.
- Discussion of applications including lung ventilation/perfusion, infectious/inflammatory processes, and oncologic imaging.
- Exploration of hybrid imaging techniques like SPECT/CT, PET/CT, and PET/MR.
Main Results:
- Nuclear medicine imaging modalities such as gamma cameras, SPECT, PET, and hybrid systems are effective in various clinical applications.
- Established applications include assessment of lung ventilation/perfusion and imaging of infectious, inflammatory, and oncologic conditions.
- Emerging techniques focus on molecular imaging and targeted tracers for diagnostics and theranostics.
Conclusions:
- Nuclear medicine and molecular imaging offer unique and valuable tools for diagnosing and treating pulmonary diseases.
- Current applications are diverse, with significant potential for future advancements in radiopharmaceuticals and targeted imaging.
- These advanced imaging techniques are vital for improving patient outcomes in pulmonology.
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