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Anticoagulation practice patterns in COVID-19: A global survey

Rachel P Rosovsky1, Kristen M Sanfilippo2, Tzu Fei Wang3

  • 1Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA USA.

Research and Practice in Thrombosis and Haemostasis
|August 25, 2020
PubMed

Insights

Current practices for managing venous thromboembolism (VTE) in COVID-19 patients vary globally. Most physicians use prophylactic anticoagulation, but more research is needed to establish optimal VTE and bleeding management strategies.

Area of Science:

  • Internal Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Optimal management of venous thromboembolism (VTE) in coronavirus disease 2019 (COVID-19) patients remains unclear due to limited data.
  • Understanding current global practices is crucial for guiding future research.

Purpose of the Study:

  • To assess worldwide physician practices in preventing, diagnosing, and managing VTE in COVID-19 patients.
  • To gather insights for designing prospective and randomized clinical trials.

Main Methods:

  • An online survey was distributed to physicians internationally.
  • The survey focused on prophylaxis, diagnosis, and treatment of VTE in COVID-19 patients.
  • Data were collected from April 10-14, 2020.

Main Results:

  • 515 physicians from 41 countries responded.
  • 78% recommended prophylactic anticoagulation for hospitalized COVID-19 patients, primarily using heparin-based treatments.
  • Observed thrombotic complications (e.g., pulmonary embolism) and bleeding complications were reported, with wide variations in incidence estimates.

Conclusions:

  • Significant variation exists in VTE management approaches for COVID-19 patients.
  • There is an urgent need for well-designed epidemiologic studies and randomized clinical trials to determine optimal anticoagulation strategies and understand VTE/bleeding risks.
Abstract

Keywords:
COVID‐19anticoagulantsbleedingblood coagulationvenous thromboembolism

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