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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Whole virus detection using aptamers and paper-based sensor potentiometry.

Subhashish Dolai¹, Massood Tabib-Azar¹

¹University of Utah 201 Presidents' Cir Salt Lake City UT USA.

Medical Devices & Sensors

|August 25, 2020

Summary

A novel paper-based sensor detects the whole Zika virus using aptamers and a potentiometric measurement. This inexpensive, flexible sensor shows potential for portable diagnostics, similar to a P-N junction.

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Last Updated: Dec 11, 2025

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Area of Science:

Biosensors
Nanotechnology
Materials Science

Background:

Paper-based sensors offer flexibility, recyclability, and low cost.
Microfluidic platforms are increasingly integrated with electronics for diagnostics.

Purpose of the Study:

To develop a paper-based potentiometric sensor for detecting the whole Zika virus.
To characterize the sensor's sensitivity and minimum detectable signal.

Main Methods:

A paper sensor was fabricated with silver paint contacts and dipped in a buffer with aptamers.
Zika virus was added, immobilizing and binding to aptamers, creating a concentration gradient.
Atomic force microscopy and Raman spectroscopy confirmed immobilization; potentiometric measurements were taken.

Main Results:

The sensor detected the whole Zika virus with a minimum sensitivity of 0.26 nV/Zika.
A minimum detectable signal (MDS) of 2.4x10^7 Zika was achieved.
Potential measurements became reproducibly more negative upon Zika addition.

Conclusions:

The paper-based potentiometric sensor effectively detects Zika virus.
The sensor functions similarly to a P-N junction, leveraging electrochemical potentials.
Integration with a liquid crystalline display (LCD) enables portable readout.