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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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[Polymyalgic complaint: is there a tumor behind it?]

Sabina Gall1, Stella Tsiami1, Jürgen Braun1

  • 1Rheumazentrum Ruhrgebiet, Ruhr-Universität Bochum.

Deutsche Medizinische Wochenschrift (1946)
|August 25, 2020
PubMed
Summary

Polymyalgia rheumatica symptoms can mask rare cancers. A retroperitoneal liposarcoma was discovered in a patient initially diagnosed with polymyalgia rheumatica, highlighting the need to consider paraneoplastic syndromes.

Area of Science:

  • Oncology
  • Rheumatology
  • Medical Diagnostics

Background:

  • A 61-year-old male presented with polymyalgia rheumatica symptoms including arm and thigh pain, weight loss, and low-grade fever.

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  • Initial diagnosis of polymyalgia rheumatica was based on clinical presentation and elevated inflammatory markers, with a positive response to prednisone therapy.