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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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An update on dengue vaccine development, challenges, and future perspectives.

Fakhriedzwan Idris1,2, Donald Heng Rong Ting1,2, Sylvie Alonso1,2

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Developing new dengue vaccines is crucial for public health, especially after Dengvaxia

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Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Dengue fever impacts over 100 countries, causing 100-400 million infections annually.
  • Vaccination is a key strategy against infectious diseases, but challenges remain for dengue vaccines.
  • The Dengvaxia vaccine faced setbacks, highlighting the need for improved dengue vaccine candidates.

Purpose of the Study:

  • To review recent dengue vaccine clinical trial outcomes.
  • To discuss novel vaccine strategies based on pathogenesis and immune correlates.
  • To identify remaining challenges in dengue vaccine development.

Main Methods:

  • Literature review of dengue vaccine clinical trials.
  • Analysis of recent advancements in dengue pathogenesis and immune correlates.
  • Discussion of emerging vaccine strategies and challenges.

Main Results:

  • Promising second-generation dengue vaccine candidates are advancing.
  • New insights into dengue pathogenesis and immune correlates are guiding vaccine design.
  • Dengue virus (DENV) strains exhibit diverse virulence mechanisms.

Conclusions:

  • Further research into adjuvants and delivery systems is needed for safer, effective, and affordable dengue vaccines.
  • The concept of a universal dengue vaccine is questioned due to DENV strain diversity.
  • Overcoming dengue-specific challenges is essential for successful vaccine implementation.