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Towards a personalised treatment approach for asthma attacks
Matthew J Martin1, Richard Beasley2, Tim W Harrison3
1Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, UK matthew.martin@nottingham.ac.uk.
Thorax
|August 26, 2020
Summary
Asthma attacks are poorly understood, leading to suboptimal treatment. This review explores risk factors and characteristics to personalize asthma attack management and reduce corticosteroid side effects.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Clinical Medicine
Background:
- Asthma exacerbations are a significant cause of UK hospital admissions and mortality.
- Current management of asthma attacks relies on bronchodilators and systemic corticosteroids.
- Asthma is recognized as heterogeneous, with personalized treatment for long-term management, but attacks remain poorly defined.
Purpose of the Study:
- To explore limitations in the description, assessment, and management of asthma attacks.
- To outline risk factors and strategies for modifying risk associated with asthma attacks.
- To describe recognized characteristics of asthma attacks for phenotyping and personalized treatment.
Main Methods:
- Literature review focusing on asthma attack description, assessment, and management.
- Identification and analysis of risk factors for asthma attacks.
- Exploration of current treatment approaches and their limitations.
Main Results:
- Asthma attacks are poorly defined and lack a standardized assessment approach.
- Current treatment strategies for asthma attacks are limited.
- Personalized treatment approaches for asthma attacks are underdeveloped.
Conclusions:
- There is a critical need to better define, assess, and phenotype asthma attacks.
- Developing personalized treatment strategies for asthma attacks is essential.
- Improving asthma attack management can reduce mortality and adverse effects of corticosteroids.
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