Related Experiment Video
Updated: Dec 11, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
The road ahead in genetics and genomics
Amy L McGuire1, Stacey Gabriel2, Sarah A Tishkoff3,4
1Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA. amcguire@bcm.edu.
Leading researchers reflect on the future of genetics and genomics, highlighting challenges and opportunities. Their insights aim to ensure the benefits of genetic and genomic research reach everyone globally.
Area of Science:
- Genetics and Genomics
Background:
- Nature Reviews Genetics celebrates its 20th anniversary.
- The field of genetics and genomics has seen significant advancements.
Purpose of the Study:
- To gather insights from 12 leading researchers on the future of genetics and genomics.
- To identify key challenges and opportunities in the field.
- To emphasize the work needed to ensure equitable benefits from genetic and genomic research.
Main Methods:
- A curated collection of perspectives from 12 prominent researchers in genetics and genomics.
- Each researcher provides a reflection based on their specific area of expertise.
Main Results:
- A comprehensive overview of the current state of genetics and genomics.
- Identification of critical areas for future research and development.
- Emphasis on the need for continued progress to achieve widespread benefits.
Conclusions:
- The field of genetics and genomics is at a pivotal point.
- Addressing current challenges is crucial for future breakthroughs.
- Collaborative efforts are needed to translate research into tangible benefits for all individuals.
Related Concept Videos
Genomics
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Evolutionary Relationships through Genome Comparisons

