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Nickel Content in Human Internal Organs
Danuta Dudek-Adamska1, Teresa Lech2, Tomasz Konopka3
1Departament of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387, Kraków, Poland. dudekd@chemia.uj.edu.pl.
This study measured nickel levels in autopsy tissues from 60 individuals in Southern Poland. Results show varying nickel concentrations, with generally lower levels in females compared to males.
Area of Science:
- Environmental Science
- Toxicology
- Human Biology
Background:
- Increasing metal concentrations in the environment pose potential health risks.
- Establishing reference levels for essential and toxic elements in biological samples is crucial.
Purpose of the Study:
- To determine nickel concentrations in autopsy tissues of non-occupationally exposed individuals in Southern Poland.
- To establish baseline nickel levels in various human organs.
Main Methods:
- Electrothermal atomic absorption spectrometry (ETAAS) was used for nickel determination.
- Microwave-assisted acid digestion was employed for sample preparation.
- A previously optimized and validated procedure was followed.
Main Results:
- Nickel levels varied widely across tissues, with ranges (ng/g wet weight): brain (2.15-79.4), stomach (0.5-44.2), liver (7.85-519), kidneys (12.8-725), lungs (8.47-333), and heart (2.3-97.7).
- Females generally exhibited lower nickel levels than males, with statistically significant differences observed in the liver, kidneys, and lungs.
- Median nickel concentrations were similar across age groups, except for the stomach.
Conclusions:
- The study provides reference nickel levels in autopsy tissues for a non-occupationally exposed population in Southern Poland.
- Observed nickel concentrations are generally consistent with previously published data.
- Sex-based differences in nickel distribution within human tissues were identified.
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