Noncovalent Interactions in C-S Bond Formation Reactions

Area of Science:

• Organic Chemistry
• Supramolecular Chemistry
• Catalysis

Background:

• Organosulfur compounds are vital components in pharmaceuticals, natural products, and advanced materials.
• Efficient synthetic methodologies for carbon-sulfur (C-S) bond formation are highly sought after in chemical synthesis.
• Supramolecular catalysis, utilizing cooperative multiple weak interactions, is an emerging and popular area for controlling chemical reactions.

Purpose of the Study:

• To compile and review literature employing multiple noncovalent interactions for aryl C-S bond-formation reactions.
• To showcase the utility of supramolecular catalysis in the synthesis of organosulfur compounds.

Main Methods:

• Literature collection focusing on aryl C-S bond-formation reactions.
• Analysis of studies utilizing various noncovalent interactions, including hydrogen bonding, solvent bonding, S-H···π, C-H···π, π-π stacking, and charge-transfer complexation.
• Examination of supramolecular catalysis approaches in these reactions.

Main Results:

• Demonstration that multiple noncovalent interactions can effectively promote aryl C-S bond formation.
• Highlighting the versatility of supramolecular catalysis in facilitating diverse C-S coupling reactions.
• Identification of key noncovalent interactions driving the catalytic efficiency.

Conclusions:

• Cooperative multiple weak interactions are powerful tools in supramolecular catalysis for C-S bond formation.
• These supramolecular strategies offer efficient and tunable pathways for synthesizing valuable organosulfur compounds.
• The reviewed literature underscores the growing importance of noncovalent interactions in modern synthetic chemistry.