[INDICATORS OF GOUT INTERLAYKINS AND THERMOGRAPHY OF JOINTS ON THE BACKGROUND OF ENTEROSORBTION THERAPY]
U Mudra1, S Andreychyn1, I Hanberher1
1I. Horbachevsky Ternopil National Medical University, Ukraine.
Georgian Medical News
|August 26, 2020
Summary
This study shows that adding carbon enterosorbent "Carboline" to standard gout treatment significantly reduces uric acid levels and inflammation markers. Thermography also indicated reduced joint hyperthermia in patients receiving the enterosorbent.
Area of Science:
- Rheumatology
- Immunology
- Biochemistry
Background:
- Gout is a metabolic disorder characterized by elevated uric acid and inflammation.
- Thermoregulation and blood flow changes are key clinical manifestations of gout.
- The efficacy of enterosorbents in managing gout has not been previously established.
Purpose of the Study:
- To investigate the impact of carbon enterosorbent "Carboline" on cytokine profiles in gout patients.
- To assess changes in local joint temperature using thermography as an indicator of gout inflammation.
- To evaluate the effectiveness of "Carboline" as an adjunct therapy for gout management.
Main Methods:
- A comparative study involving 65 gout patients and 30 healthy controls.
- Patients were divided into two groups: basic therapy alone and basic therapy plus "Carboline".
- Serum uric acid, IL-1β, TNF-α, and IL-10 levels were measured, along with joint thermography before and after treatment.
Main Results:
- Gout patients exhibited higher uric acid, pro-inflammatory (IL-1β, TNF-α), and anti-inflammatory (IL-10) cytokines compared to controls.
- Joint thermography revealed significant hyperthermia in affected joints of gout patients.
- Treatment with "Carboline" led to greater reductions in uric acid, cytokines, and joint temperature compared to basic therapy alone.
Conclusions:
- Carbon enterosorbent "Carboline" is effective in reducing uric acid and inflammatory markers in gout patients.
- Thermographic assessment indicates a reduction in joint inflammation with "Carboline" therapy.
- "Carboline" shows promise as an effective addition to comprehensive gout treatment strategies.
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