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Global differences in atopic dermatitis.

Noor H A Suaini1,2, Cheryl P T Tan3, Evelyn X L Loo1,3

  • 1Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|August 26, 2020
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) prevalence and presentation vary globally. Research must include diverse ethnicities to understand AD

Keywords:
Asiaatopic dermatitischildeczemaenvironmentethnic diversitygeneticsglobalimmuno-phenotypestailored treatment

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Area of Science:

  • Dermatology and Immunology
  • Epidemiology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition with increasing prevalence in the Asia Pacific.
  • Existing research predominantly focuses on Western populations, with limited data on ethnic variations in AD.
  • Understanding ethnic differences in AD pathogenesis and clinical presentation is crucial.

Purpose of the Study:

  • To review global literature on atopic dermatitis (AD) prevalence.
  • To highlight ethnic variations in clinical and immunological phenotypes of AD.
  • To discuss factors influencing AD across diverse populations and therapeutic implications.

Main Methods:

  • Systematic review of existing literature on AD prevalence and phenotypes.
  • Analysis of studies reporting on genetic and environmental factors in different ethnic groups.
  • Evaluation of therapeutic considerations in the context of ethnic diversity.

Main Results:

  • Significant global variability in AD prevalence and clinical manifestations exists.
  • Ethnic and geographical differences in AD phenotypes are evident, impacting treatment responses.
  • Genetic and environmental factors contribute to inter-ethnic heterogeneity in AD.

Conclusions:

  • Atopic dermatitis exhibits significant ethnic-dependent clinical and immunological heterogeneity.
  • Current treatments, including biologics, may need tailoring based on specific immuno-phenotypes.
  • Future research requires greater ethnic diversity to develop targeted and effective AD treatments.