Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.4K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.4K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.3K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Radiomodulatory Effects of Sodium Aminodihydrophthalazinedione (Tameron<sup>®</sup>) on Normal and Cancer Cells Cultures: Antioxidant Activity, DNA Damage Response, and Transcriptomic Profiling.

International journal of molecular sciences·2026
Same author

A spatial atlas of the healthy human liver from live donors.

Nature·2026
Same author

Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors.

bioRxiv : the preprint server for biology·2026
Same author

Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion.

The Journal of cell biology·2026
Same author

How do authors want to use AI for review? : A survey to assess the perception of scientists who received both AI and human reviews of their manuscripts.

EMBO reports·2026
Same author

Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.

Nature neuroscience·2025
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: Dec 11, 2025

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

4.4K

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans.

Leah Houri-Zeevi1, Yael Korem Kohanim2, Olga Antonova1

  • 1Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.

Cell
|August 26, 2020
PubMed
Summary
This summary is machine-generated.

Transgenerational small RNA inheritance in C. elegans is stochastic. HSF-1 regulates inheritance states, influencing progeny's stress response and developmental rate.

More Related Videos

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans

Published on: February 13, 2012

17.5K
Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans
11:22

Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans

Published on: February 13, 2013

12.7K

Related Experiment Videos

Last Updated: Dec 11, 2025

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

4.4K
RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans

Published on: February 13, 2012

17.5K
Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans
11:22

Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans

Published on: February 13, 2013

12.7K

Area of Science:

  • Epigenetics and gene regulation
  • Developmental biology
  • RNA interference (RNAi) mechanisms

Background:

  • Transgenerational epigenetic inheritance allows traits to pass across generations.
  • Small RNAs mediate heritable gene silencing in response to environmental cues.
  • The mechanisms governing the segregation and persistence of these RNA-based responses are not fully understood.

Purpose of the Study:

  • To investigate the population-level segregation of transgenerational small RNA-based responses in C. elegans.
  • To identify the factors and principles governing the inheritance and dissipation of RNAi.
  • To explore the relationship between inheritance states and offspring phenotypes.

Main Methods:

  • Analysis of over 20,000 worm lineages to track RNAi persistence.
  • Stochastic modeling of inheritance states and their effects on progeny.
  • Investigation of the role of Heat Shock Factor 1 (HSF-1) in regulating silencing factors and small RNA levels.

Main Results:

  • Individual C. elegans lineages exhibit significant variation in transgenerational RNAi persistence.
  • Heritable RNAi is uniformly distributed among descendants but dissipates over generations.
  • Maternal 'inheritance states,' regulated by HSF-1, stochastically determine the fate and heritability of RNAi.
  • The duration of RNAi inheritance correlates with its likelihood of continued inheritance.
  • Parental inheritance state predicts offspring developmental rate under stress.

Conclusions:

  • Transgenerational RNAi inheritance in C. elegans is a stochastic process influenced by maternal inheritance states.
  • HSF-1 plays a critical role in regulating these inheritance states and downstream small RNA dynamics.
  • Understanding these inheritance mechanisms provides insights into predicting offspring responses to environmental challenges.