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Drug resistance in ostertagiasis
1Department of Zoology, University of Massachusetts, Amherst 01003.
Veterinary Parasitology
|February 1, 1988
Summary
Anthelmintic resistance in cattle worms Ostertagia ostertagi is not currently a problem but could become serious. Factors like worm biology and drug metabolism may contribute to potential resistance development.
Area of Science:
- Veterinary Parasitology
- Drug Resistance Studies
Background:
- Anthelmintic resistance is documented in sheep parasites like Ostertagia circumcincta.
- No confirmed cases of anthelmintic resistance in cattle parasite Ostertagia ostertagi exist, despite controlled trial evidence.
Purpose of the Study:
- To explore potential reasons for the lack of reported anthelmintic resistance in Ostertagia ostertagi in cattle.
- To identify factors that may contribute to the emergence of anthelmintic resistance in cattle parasites.
Main Methods:
- Review of existing literature on anthelmintic resistance in ruminant parasites.
- Analysis of factors influencing drug efficacy and resistance development in Ostertagia ostertagi.
- Consideration of biological, host, and management factors.
Main Results:
- Several factors may explain the absence of reported resistance, including worm biology, drug metabolism, and lower anthelmintic usage in cattle compared to sheep.
- Reduced efficacy of levamisole, thiabendazole, and benzimidazoles against specific stages of Ostertagia ostertagi in cattle has been observed.
- Stage-specific resistance, particularly in inhibited L4 larvae against benzimidazoles, is a potential concern.
Conclusions:
- While not currently a significant issue, anthelmintic resistance in Ostertagia ostertagi poses a potential future threat to cattle health.
- Further research and vigilant monitoring are necessary to prevent the widespread development of resistance.