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Published on: December 6, 2016
Sleep-disordered breathing in cystic fibrosis
Aarti Shakkottai1, Samya Z Nasr2, Fauziya Hassan1
1Sleep Disorders Center and Department of Neurology, Michigan Medicine, Ann Arbor, MI, USA; Pediatric Pulmonology, Department of Pediatrics and Communicable Diseases, Michigan Medicine, Ann Arbor, MI, USA.
Patients with cystic fibrosis (CF) have a higher likelihood of experiencing sleep-disordered breathing (SDB). Lung function does not predict SDB severity, indicating a need for routine screening.
Area of Science:
- Pulmonology
- Sleep Medicine
- Genetics
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting ~30,000 Americans.
- Patients with CF often report sleep disturbances like snoring and insomnia.
- The link between CF and sleep-disordered breathing (SDB) is not well understood.
Purpose of the Study:
- To investigate the prevalence and severity of SDB in patients with CF compared to non-CF individuals.
- To explore the relationship between CF lung disease severity and SDB.
- To determine if lung function predicts SDB severity in CF patients.
Main Methods:
- Retrospective review of polysomnography data from CF and matched non-CF patients.
- Individual matching based on age, gender, race, and BMI.
- Analysis of apnea-hypopnea index (AHI) and nocturnal oxygen saturation (Minimum SpO2).
Main Results:
- CF patients had three times greater odds of moderate-to-severe SDB (AHI ≥ 5/≥ 15).
- CF patients exhibited lower nocturnal oxygen saturation nadir (Minimum SpO2).
- Lower lung function (FEV1 PPD) in CF patients correlated with lower Minimum SpO2 and exacerbated AHI effects.
Conclusions:
- Referred CF patients show increased SDB severity compared to non-CF individuals.
- SDB may influence the relationship between CF lung disease and nocturnal hypoxemia.
- Routine polysomnography is recommended for CF patients due to lack of lung function prediction for SDB severity.
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