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Updated: Dec 11, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Research on the correlation between otorhinolaryngologic diseases and environmental meteorological factors in
Xinlan Wang1,2, Mei Wang1,2, Jinyan Wang3
1Department of Otolaryngology Head and Neck Surgery,the 940thHospital of the Joint Logistics Support Unit of the Chinese PLA,Lanzhou,730050,China.
Insights
Environmental factors like air quality and temperature correlate with childhood illnesses such as acute otitis media (AOM), acute pharyngitis (AP), and allergic rhinitis (AR), with seasonal and lag effects observed.
Area of Science:
- Environmental Health
- Pediatric Medicine
- Otolaryngology
Background:
- Childhood respiratory and ear infections are common, with potential links to environmental conditions.
- Understanding these links is crucial for public health interventions and prevention strategies.
Purpose of the Study:
- To investigate the association between environmental-meteorological factors and the incidence of acute otitis media (AOM), acute pharyngitis (AP), and allergic rhinitis (AR) in children.
- To analyze the seasonal variations and lag effects of these environmental factors on pediatric AOM, AP, and AR.
Main Methods:
- Retrospective analysis of clinical data from pediatric patients diagnosed with AOM, AP, or AR between 2015-2017.
- Correlation analysis between disease incidence and environmental-meteorological data, including Air Quality Index (AQI), particulate matter (PM2.5, PM10), gaseous pollutants (CO, NO₂, SO₂, O3), temperature, air pressure, wind speed, and humidity.
Main Results:
- Incidence of AOM showed positive correlations with AQI, PM2.5, PM10, CO, NO₂, SO₂, and air pressure; negative correlations with O3, wind speed, and temperature.
- AP incidence was positively correlated with temperature and humidity.
- AR incidence was correlated with most environmental factors except O3.
- All three conditions exhibited seasonal variations and demonstrated single and cumulative lag effects from environmental factors.
Conclusions:
- Environmental-meteorological factors are significantly associated with the incidence of pediatric AOM, AP, and AR.
- These associations exhibit seasonal patterns and delayed (lag) effects, highlighting the complexity of environmental influences on childhood illnesses.
- Further research into these relationships can inform targeted public health strategies for managing these common pediatric conditions.
Abstract:
Objective:To explore the correlation between acute otitis media(AOM), acute pharyngitis(AP) and allergic rhinitis(AR) and environmental-meteorological factors in children in Lanzhou. Method:Data were collected in 2015-2017 from the outpatient department and emergency department of Otolaryngology of one hospital in Lanzhou. The association between clinical data and the environmental meteorological factors during the same period, including the air quality index(AQI), PM2.5, PM10, CO, NO₂, SO₂, O3, average temperature, average air pressure, average wind speed, average humidity in Lanzhou, was analyzed. Result:The incidence of AOM was positively correlated with AQI, PM2.5, PM10, CO, NO₂, SO₂, average air pressure, and was negatively correlated with O3, average wind speed and average air temperature, but not correlated with average humidity. The incidence of AP was positively correlated with average temperature and average humidity, and not correlated with other 9 factors. The incidence of AR was correlated with all 10 environmental meteorological factors except for O3.The number of children with AOM, AP and AR varied with different seasons. Environmental meteorological factors have single lag and cumulative lag effects on the incidence of children with AOM, AP and AR, and difference between the single lag and cumulative lag time was observed. Conclusion:There may be some correlation between the environmental meteorological factors and the incidence of AOM, AP, AR in children, and there is a lag effect. The incidence of pediatric AOM, AP and AR is affected by seasonal factors.
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