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Updated: Dec 11, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.1K

[Comparative study of three methods in the diagnosis of laryngopharyngeal reflux in children]

Zhiwei Qi1, Shujun Zhang1, Xuehong Zhang1

  • 1Department of Otorhinolaryngology，Affiliated Hospital of Chengde Medical College，Chengde，067000，China.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|August 26, 2020
PubMed

Insights

Pepsin detection is a reliable and cost-effective method for diagnosing laryngopharyngeal reflux (LPR) in children. This non-invasive test shows high sensitivity and specificity, making it a valuable diagnostic tool.

Area of Science:

  • Pediatric Gastroenterology
  • Otolaryngology

Background:

  • Laryngopharyngeal reflux (LPR) is a challenging condition to diagnose in children.
  • Current diagnostic methods like the Reflux Symptom Index (RSI), Reflux Finding Score (RFS), and 24-hour dual-probe pH monitoring have limitations.

Purpose of the Study:

  • To compare the diagnostic consistency of pepsin detection, 24-hour dual-probe pH monitoring, RSI, and RFS in pediatric LPR.
  • To evaluate the sensitivity and specificity of these diagnostic tools.

Main Methods:

  • Retrospective analysis of 76 children with suspected LPR.
  • Simultaneous assessment using RSI, RFS, pepsin detection, and 24-hour dual-probe pH monitoring.
  • Calculation of diagnostic consistency (Kappa values), sensitivity, and specificity.

Main Results:

  • Pepsin detection demonstrated high sensitivity (95.31%) and specificity (100%).
  • Diagnostic consistency was good between pepsin detection and scales (Kappa > 0.75).
  • Pepsin detection and 24-hour pH monitoring showed moderate consistency (Kappa = 0.467).

Conclusions:

  • Pepsin detection is a reliable, objective, economical, and non-invasive biomarker for diagnosing pediatric LPR.
  • Its ease of implementation makes it a practical tool for widespread clinical use.

Keywords:
laryngeal refluxpH monitoringpepsinreflux finding scorereflux symptom index

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