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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Related Experiment Video

Updated: Dec 11, 2025

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
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Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

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[Progress in research on olfactory epithelial regeneration].

Qingqing Xu, Xiangdong Wang, Luo Zhang

    Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
    |August 26, 2020
    PubMed
    Summary
    This summary is machine-generated.

    The olfactory epithelium (OE) can regenerate, but damage from diseases or trauma causes olfactory dysfunction. Understanding OE regeneration mechanisms is key to developing new treatments for smell disorders.

    Keywords:
    olfactory epitheliumregulatory mechanismreproductiontreatment

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    Isolating Nasal Olfactory Stem Cells from Rodents or Humans
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    Area of Science:

    • Neuroscience
    • Regenerative Medicine
    • Otolaryngology

    Background:

    • The olfactory epithelium (OE) is a neuro-epithelial tissue with regenerative capacity.
    • Olfactory dysfunction, resulting from neurodegenerative diseases, trauma, or infections, significantly impacts health and quality of life.
    • Current understanding of OE regeneration mechanisms and effective treatments for olfactory disorders remains incomplete.

    Purpose of the Study:

    • To review the composition of the olfactory epithelium and olfactory stem cells.
    • To elucidate the regulation of olfactory sensory neuron regeneration under physiological and pathological conditions.
    • To explore potential therapeutic strategies for olfactory disorders.

    Main Methods:

    • Literature review of existing research on olfactory epithelium regeneration.
    • Analysis of studies on olfactory stem cell composition and function.
    • Synthesis of findings on the regulation of olfactory sensory neuron regeneration.
    • Review of current and emerging treatments for olfactory dysfunction.

    Main Results:

    • The olfactory epithelium possesses inherent regenerative capabilities.
    • Various factors can impair OE regeneration, leading to olfactory dysfunction.
    • Olfactory stem cells play a crucial role in OE repair.
    • Understanding regeneration pathways offers targets for therapeutic intervention.

    Conclusions:

    • Clarifying the mechanisms governing OE regeneration is essential for addressing olfactory dysfunction.
    • Further research into OE stem cells and regeneration pathways can lead to novel treatments.
    • Effective management of olfactory disorders requires a comprehensive understanding of OE biology.