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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Teeth01:15

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Regulation of Angiogenesis and Blood Supply01:24

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Determination01:51

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

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Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Related Experiment Video

Updated: Dec 11, 2025

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

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[Mechanisms and regulations in tooth root development].

Y N Zhang1, J Wang1, C C Zhou1

  • 1Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology
|August 27, 2020
PubMed
Summary
This summary is machine-generated.

Understanding tooth root development is key to regeneration. This review details signaling pathways crucial for tooth root formation, offering insights for treating tooth loss.

Keywords:
DentinEpithelial root sheathSignaling pathwayTooth rootTooth root development

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Area of Science:

  • Biomedical Science
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Tooth loss significantly impacts health due to trauma, periodontitis, or genetic disorders.
  • The tooth root anchors teeth within the alveolar socket, connecting to periodontal tissues.
  • Understanding tooth root development is vital for advancing regenerative therapies.

Purpose of the Study:

  • To review current research on molecular mechanisms governing tooth root development.
  • To highlight the role of signaling pathways in this complex process.

Main Methods:

  • Literature review of scientific articles on tooth root development.
  • Analysis of signaling pathways involved in epithelial-mesenchymal interactions during root formation.

Main Results:

  • Tooth root development involves intricate communication between epithelial and mesenchymal tissues.
  • Multiple signaling pathways regulate the developmental process.
  • Specific pathways are identified as critical for root formation.

Conclusions:

  • Elucidating signaling pathways in tooth root development is essential for discovering novel regenerative strategies.
  • Further research into these pathways could lead to treatments for conditions causing tooth loss.