[Local autovaccine treatment of experimental urinary tract infections in the rat]

The effect of a local autovaccination therapy on the course of an experimental pyelonephritis should be investigated in the rat. A total of 114 animals were infected by E. coli O2:K1:H4 by the hematogenic route. In the first group a suspension of formalin-inactivated germs of the infection strain was applicated, in the second group a suspension of formalin-inactivated germs of a E. coli rough strain and in the third group isotonic saline solution was given on the 6th, 7th, and 8th week after infection, respectively. The fourth group was untreated after infection. The autovaccination therapy led to a significantly decrease of bacterially contaminated kidneys and a significantly reduction of pyelonephritis foci in the primary infected kidneys. An ascending reinfection resulted in a higher bacterial colonization of the kidneys in the vaccinated animals than in the control animals. Nevertheless, in the vaccinated animals fewer kidneys were affected by inflammatory changes.