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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0
Sheila Siqueira Andrade1, Alessandra Valéria de Sousa Faria2,3, Manoel João Batista C Girão4
1PlateInnove Biotechnology, Piracicaba, SP 13414-018, Brazil.
International Journal of Molecular Sciences
|August 27, 2020
Summary
Platelets are highly biotechnological cells with advanced applications in tissue regeneration. This review explores biotech-educated platelets and biomimetic science for novel tissue engineering solutions beyond current regeneration 2.0 concepts.
Area of Science:
- Biotechnology
- Biomaterials Science
- Tissue Engineering
Background:
- Recent discoveries highlight platelets as key biotechnological human cells.
- Platelets possess unique responsive and secretory functions.
- Platelet biology and functions have advanced significantly in the last decade.
Purpose of the Study:
- To review advances in platelet biology and functions.
- To introduce the concept of biotech-educated platelets.
- To explore the connection between biomimetic science and platelet-based additive manufacturing for tissue regeneration.
Main Methods:
- Literature review of recent advancements in platelet biology.
- Synthesis of concepts linking biomimetic science with platelet applications.
- Exploration of additive manufacturing techniques for platelet-based biomaterials.
Main Results:
- Platelets offer significant potential for developing advanced biomaterials.
- Biotech-educated platelets can be engineered with instructive extracellular cues.
- Platelet-based solutions can modify injured microenvironments for morphogenesis.
Conclusions:
- Platelets are versatile cells for innovative tissue engineering.
- Biomimetic approaches enhance platelet-based regenerative strategies.
- Future applications extend beyond current tissue regeneration 2.0.
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