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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Infections in systemic autoimmune diseases.

Reumatologia clinica·2021
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Infections in systemic autoimmune diseases.

Sandra Andrea Consani Fernández1, Carolina Laura Díaz Cuña2, Lucía Fernández Rey3

  • 1Profesora adjunta de Clínica Médica «3». Hospital Maciel. Udelar. Montevideo. Uruguay.

Reumatologia Clinica
|August 27, 2020
PubMed
Summary

Infections are common in patients with systemic autoimmune diseases (SAD), particularly rheumatoid arthritis (RA). Treatments like corticosteroids and biologics increase infection risk, highlighting the need for prophylaxis.

Keywords:
Enfermedades autoinmunes sistémicasImmunosuppressive treatmentInfeccionesInfectionsSystemic autoimmune diseasesTratamiento inmunosupresor

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Clinical Immunology

Background:

  • Infections pose significant morbidity and mortality risks for patients with systemic autoimmune diseases (SAD).
  • Understanding infection frequency in relation to specific SAD types and treatments is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of infections in a historical cohort of SAD patients.
  • To analyze infection rates based on specific disease types and treatments received.

Main Methods:

  • Retrospective observational study of 339 SAD patients from January 2012 to February 2019.
  • Analysis of infectious complications stratified by disease and treatment modalities.

Main Results:

  • 46.9% of patients experienced infectious complications, predominantly non-opportunistic (95%).
  • Respiratory (48.6%), urinary (31.7%), and skin infections (17.6%) were most common.
  • Methotrexate, mycophenolate, corticosteroids, and biological therapies were associated with increased infection risk. Hydroxychloroquine and sulfasalazine showed a protective effect in RA patients.

Conclusions:

  • Infections are frequent in rheumatoid arthritis (RA) due to disease-related immune dysregulation and treatments like corticosteroids and biologics.
  • Prophylactic measures and screening are essential before initiating treatment in SAD patients.