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Pharmacogenomics cascade testing (PhaCT): a novel approach for preemptive pharmacogenomics testing to optimize
Don Roosan1, Angela Hwang2, Moom R Roosan3
1Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA. droosan@westernu.edu.
The Pharmacogenomics Journal
|August 27, 2020
Summary
Patients are willing to share pharmacogenomics (PGx) results to facilitate pharmacogenomics cascade testing (PhaCT) for family members. A new informatics platform can enable this sharing, improving precision medicine and patient empowerment.
Area of Science:
- Genetics and Genomics
- Clinical Pharmacology
- Health Informatics
Background:
- Pharmacogenomics (PGx) implementation in clinical practice has advanced significantly.
- The potential benefits of sharing PGx results among family members remain largely unexplored.
- Family medication history can aid in identifying candidates for pharmacogenomics cascade testing (PhaCT).
Purpose of the Study:
- To explore patient willingness to share PGx results.
- To assess the utility of family medication history in identifying candidates for PhaCT.
- To propose a novel informatics platform to facilitate PGx data sharing and PhaCT.
Main Methods:
- Investigated patient willingness to share PGx data.
- Explored the use of family medication history for identifying potential PhaCT candidates.
- Proposed a HIPAA-compliant, shareable informatics platform for managing PGx results and facilitating family testing.
Main Results:
- Patients show willingness to share PGx results, supporting the concept of PhaCT.
- Family genetic similarities can help identify potential gene variants for preemptive testing.
- A proposed informatics platform can integrate with EHRs and empower patients in managing and sharing genomic data.
Conclusions:
- Sharing PGx results and implementing PhaCT can enhance precision medicine.
- A novel informatics platform is proposed to enable secure PGx data sharing and support PhaCT.
- Empowering patients with tools to share their PGx information can improve medication adherence and health management distribution.
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