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Related Experiment Video

Updated: Dec 10, 2025

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection

Published on: November 3, 2012

Update on Herpes simplex keratitis management.

Daniel Sibley¹, Daniel F P Larkin^2,3,4

¹Cornea & External Diseases Service, Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, UK.

Eye (London, England)

|August 27, 2020

Summary

This summary is machine-generated.

Herpes simplex keratitis (HSK) is a common cause of blindness. This review covers diagnostic methods like PCR and discusses treatment strategies for HSK, including managing non-responsive cases.

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Last Updated: Dec 10, 2025

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Area of Science:

Ophthalmology
Virology
Infectious Diseases

Background:

Herpes simplex keratitis (HSK) is a frequent and potentially blinding corneal infection.
Recurrent HSK infections can lead to progressive corneal scarring and vision loss.
Effective management of HSK is crucial for reducing disease duration and preventing further recurrences.

Purpose of the Study:

To review diagnostic laboratory investigations for HSK, including polymerase chain reaction (PCR), viral culture, and immunohistochemistry.
To discuss current treatment strategies for HSK.
To explore management options for HSK cases that do not respond to standard treatments.

Main Methods:

Literature review of diagnostic techniques for HSK.
Review of established and emerging treatment modalities for HSK.
Analysis of clinical approaches for refractory HSK.

Main Results:

Comparison of the advantages of PCR, viral culture, and immunohistochemistry in HSK diagnosis.
Overview of current therapeutic options for managing HSK recurrences.
Discussion of challenges and strategies for treating non-responsive HSK.

Conclusions:

Accurate diagnosis is essential for effective HSK management.
Timely treatment of HSK recurrences can prevent vision loss.
Management of refractory HSK requires careful consideration of treatment options.