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Acromegaly: a clinical perspective.
Lima Lawrence1, Kenda Alkwatli1, James Bena2
1Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, 9500 Euclid Ave. F-20, Cleveland, OH 44195 USA.
Clinical Diabetes and Endocrinology
|August 27, 2020
Summary
Acromegaly treatment is effective with surgery, often combined with medication or radiation. Higher IGF-1 levels and tumor invasion predict poorer surgical outcomes in acromegaly patients.
Area of Science:
- Endocrinology
- Neurosurgery
- Oncology
Background:
- Acromegaly is a rare endocrine disorder caused by excess growth hormone (GH).
- Understanding clinical profiles and treatment outcomes is crucial for managing acromegaly.
Purpose of the Study:
- To analyze clinical and hormonal profiles of acromegaly patients.
- To evaluate treatment patterns, surgical pathology, and outcomes over 15 years.
Main Methods:
- Retrospective chart review of 136 acromegaly patients undergoing surgery (2003-2018).
- Analysis of clinical data, hormonal levels (IGF-1), tumor characteristics, and treatment responses.
Main Results:
- Most patients had macroadenomas (82.2%) with GH immunoreactivity.
- 64.0% achieved complete tumor resection; 70.1% had surgical cure alone.
- Higher IGF-1 and cavernous sinus invasion predicted surgical failure.
Conclusions:
- Surgery alone or with adjuvant therapy is effective for acromegaly.
- Further research into biomarkers and imaging is needed for personalized treatment.
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