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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Acromegaly: a clinical perspective.

Lima Lawrence1, Kenda Alkwatli1, James Bena2

  • 1Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, 9500 Euclid Ave. F-20, Cleveland, OH 44195 USA.

Clinical Diabetes and Endocrinology
|August 27, 2020
PubMed
Summary
This summary is machine-generated.

Acromegaly treatment is effective with surgery, often combined with medication or radiation. Higher IGF-1 levels and tumor invasion predict poorer surgical outcomes in acromegaly patients.

Keywords:
AcromegalyGrowth hormoneIGF-1Pituitary adenomaSparsely granulated

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Acromegaly is a rare endocrine disorder caused by excess growth hormone (GH).
  • Understanding clinical profiles and treatment outcomes is crucial for managing acromegaly.

Purpose of the Study:

  • To analyze clinical and hormonal profiles of acromegaly patients.
  • To evaluate treatment patterns, surgical pathology, and outcomes over 15 years.

Main Methods:

  • Retrospective chart review of 136 acromegaly patients undergoing surgery (2003-2018).
  • Analysis of clinical data, hormonal levels (IGF-1), tumor characteristics, and treatment responses.

Main Results:

  • Most patients had macroadenomas (82.2%) with GH immunoreactivity.
  • 64.0% achieved complete tumor resection; 70.1% had surgical cure alone.
  • Higher IGF-1 and cavernous sinus invasion predicted surgical failure.

Conclusions:

  • Surgery alone or with adjuvant therapy is effective for acromegaly.
  • Further research into biomarkers and imaging is needed for personalized treatment.