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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Updated: Dec 10, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Keloids: Current and emerging therapies.

Nkemcho Ojeh1, Ambadasu Bharatha1, Uma Gaur1

  • 1Faculty of Medical Sciences, The University of the West Indies, Cave Hill Campus, Bridgetown, Barbados, West Indies.

Scars, Burns & Healing
|August 27, 2020
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Summary
This summary is machine-generated.

Keloids are difficult-to-treat scars that impact quality of life. This review explores current and emerging keloid treatments, highlighting combinational therapies for better patient outcomes.

Keywords:
Keloidsmanagementrecurrencescartreatmentwound healing

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Area of Science:

  • Dermatology and wound healing research.
  • Pathological scar formation and management.

Background:

  • Keloids are problematic scars resulting from impaired wound healing, often recurring and impacting quality of life.
  • Current treatments are not universally satisfactory, posing a clinical challenge.
  • The exact causes of keloids are not fully understood, but research is advancing.

Purpose of the Study:

  • To review current and emerging therapeutic options for keloid management.
  • To explore the aetiopathogenesis of keloids and potential new treatment avenues.

Main Methods:

  • Literature review of general concepts in keloid development.
  • Summary of current treatments including corticosteroids, surgery, silicone, pressure, radiotherapy, cryotherapy, laser, imiquimod, and 5-fluorouracil.
  • Overview of emerging therapies such as stem cells, mitomycin C, verapamil, interferons, bleomycin, botulinum toxin, and ACE inhibitors.

Main Results:

  • No single treatment is optimal for all keloid subtypes.
  • Combinational therapeutic approaches often yield better patient satisfaction than monotherapy.
  • Advances in molecular biology and genetics are providing insights into scar formation.

Conclusions:

  • Further understanding of keloid aetiopathogenesis may lead to novel, more efficacious treatments.
  • Developing optimal therapeutic strategies for all keloid types remains a significant clinical challenge.
  • Combinational therapies show promise for improved keloid management.