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Acute lymphoblastic leukemia in a β-thalassemia intermedia child: A case report
Laila M Sherief1, Esmael Goneim2, Naglaa M Kamal3
1Department of Pediatric Hematology and Oncology, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt.
Background:
β-thalassemia intermedia (βTI) is one of the hemoglobinopathies. It constitutes 10% of β-thalassemia cases yet being associated with a better quality of life than β-thalassemia major (βTM).
Case Summary:
We recently reported the first case of acute lymphoblastic leukemia (ALL) from Egypt in a child with βTM, and we herein report the first case of ALL from Egypt in a child with βTI. In this report, literature was reviewed for cases of malignancies associated with βTI and the possible factors underling the relationship between the two entities.
Conclusion:
We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.
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