ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
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Updated: Dec 10, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Fedaa Ali1, Menattallah Elserafy2, Mohamed H Alkordi3
1Department of Sciences, University College Groningen, University of Groningen, Hoendiepskade 23/24, 9718, BG Groningen, Netherlands.
Abstract:
The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.
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