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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
Published on: November 30, 2016
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Colorectal liver metastases: radiopathological correlation
Luisa Paulatto1, Marco Dioguardi Burgio1,2,3, Riccardo Sartoris1,2,3
1Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Hauts-de-Seine, Clichy, France.
Insights Into Imaging
|August 27, 2020
Summary
Radiologists must understand imaging features of colorectal liver metastases (CRLM) before and after treatment. This knowledge aids in assessing treatment response and predicting outcomes in CRLM patients.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Colorectal liver metastases (CRLM) survival has improved due to advancements in chemotherapy, targeted therapies, and surgery.
- Imaging is crucial for CRLM diagnosis, staging, and treatment decisions.
- Radiologists need to recognize imaging characteristics of untreated CRLM and treatment-induced changes for accurate interpretation.
Purpose of the Study:
- To illustrate the significance of imaging features of colorectal liver metastases during systemic therapy.
- To correlate imaging findings with pathological tumor response and biology.
- To enhance radiologists' ability to interpret CRLM changes post-treatment.
Main Methods:
- Review of imaging features of untreated and treated colorectal liver metastases.
- Correlation of imaging findings with pathological tumor response.
- Illustrative examples of radiopathological correlations in CRLM.
Main Results:
- Untreated CRLM show distinct imaging patterns (necrosis, proliferation, desmoplasia, mucin/fibrosis).
- Post-treatment, viable tumor is replaced by necrosis and fibrosis, with residual cells peripherally.
- Imaging changes can predict treatment response but may mimic pre-treatment appearance; peripheral halos indicate treatment resistance or interruption.
Conclusions:
- Understanding pre- and post-treatment imaging features of CRLM is essential for accurate assessment.
- Radiopathological correlation aids in interpreting treatment effects and predicting tumor response.
- Familiarity with imaging nuances improves patient management and stratification for colorectal liver metastases.
