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Updated: Dec 10, 2025

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
Published on: July 29, 2019
The jury is still out regarding the generality of adaptive 'transgenerational' effects
Alfredo Sánchez-Tójar1, Malgorzata Lagisz2, Nicholas P Moran1
1Department of Evolutionary Biology, Bielefeld University, Bielefeld, Germany.
Abstract:
A recent meta-analysis concluded, 'transgenerational effects are widespread, strong and persistent'. We identify biases in the literature search, data and analyses, questioning that conclusion. Re-analyses indicate few studies actually tested transgenerational effects - making it challenging to disentangle condition-transfer from anticipatory parental effects, and providing little insight into the underlying mechanisms.
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