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Pricing methods in outcome-based contracting: δ3: reference-based pricing.

Nimer S Alkhatib1,2, Brian Erstad1,3, Kenneth Ramos4

  • 1Center for Health Outcomes and PharmacoEconomic Research, College of Pharmacy, University of Arizona, Tucson, AZ, USA.

Journal of Medical Economics
|August 27, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a Six Delta platform for outcome-based drug pricing, using international price referencing for non-small cell lung cancer treatment. The method successfully estimated drug prices, demonstrating platform viability.

Keywords:
C00D40Reference pricinglung cancerosimertiniboutcome-based-contractingpricing methods

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Area of Science:

  • Health Economics
  • Pharmaceutical Pricing
  • Oncology

Background:

  • Outcome-based contracting is a key strategy in pharmaceutical pricing.
  • International drug price referencing offers a method for setting fair prices.
  • A standardized platform is needed to integrate these approaches.

Purpose of the Study:

  • To describe the methodology of the third dimension (δ3) of the Six Delta platform, which uses international drug price referencing.
  • To present a proof-of-concept application of this dimension for osimertinib in non-small cell lung cancer (NSCLC).

Main Methods:

  • A six-step process for reference-based pricing was developed, including country selection, exchange rate and inflation adjustments, scenario generation, and Monte Carlo Simulation (MCS).
  • The methodology was applied to hypothetical 1-year and 2-year outcome-based contracts for osimertinib in NSCLC.
  • Key criteria for country selection included drug availability, price data, OECD membership, and value assessment in pricing.

Main Results:

  • The United Kingdom and Canada met the selection criteria for reference countries.
  • For a 1-year contract, the estimated drug price was $9,395 (35.72% below WAC) after inflation adjustments.
  • For a 2-year contract, the estimated drug price was $9,442 (35.40% below WAC).

Conclusions:

  • International price referencing methods can be effectively integrated into the Six Delta platform.
  • The platform provides a viable framework for outcome-based drug pricing and contracting.
  • The proof-of-concept demonstrates the practical application of the methodology.