Related Experiment Video
Updated: Dec 10, 2025

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
What you need to know about brain abscesses
Marta De Andres Crespo1, Chris McKinnon1, Jane Halliday1
1Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Abstract:
A brain abscess is a focal accumulation of pus in the brain parenchyma arising from direct inoculation, contiguous spread from local anatomical structures or haematogenous seeding from a remote source of infection. It can result in significant morbidity and mortality, making early diagnosis and treatment vital. Only one fifth of patients present with the classic triad of headache, fever and focal neurological symptoms. More commonly patients show signs and symptoms of raised intracranial pressure alone, such as confusion or reduced conscious level, headache, nausea and vomiting, which can be a presentation of many intracranial pathologies. Distinguishing an abscess from other pathologies such as meningitis and tumours is crucial, as clinically these can present in similar ways, but their management and outcomes are very different. Diffusion-weighted magnetic resonance imaging brain scans can help localise the lesion and differentiate ring-enhancing lesions caused by a brain abscess from malignant tumours. Cerebral abscesses are considered a neurosurgical emergency; early stabilisation, diagnosis and management in a neurosurgical centre is important in reducing morbidity and mortality.
Insights
A brain abscess is a pus accumulation in the brain requiring prompt diagnosis and treatment. Advanced MRI scans help differentiate abscesses from tumors, improving patient outcomes.
Area of Science:
- Neurology
- Neurosurgery
- Infectious Diseases
Background:
- Brain abscesses are focal pus accumulations in the brain parenchyma.
- They can lead to significant morbidity and mortality, necessitating early diagnosis and treatment.
- Clinical presentation is often non-specific, mimicking other intracranial pathologies.
Purpose of the Study:
- To highlight the importance of early diagnosis and management of brain abscesses.
- To differentiate brain abscesses from other intracranial lesions.
- To emphasize the role of advanced imaging in diagnosis.
Main Methods:
- Review of clinical presentations and diagnostic challenges of brain abscesses.
- Emphasis on the utility of diffusion-weighted magnetic resonance imaging (MRI).
- Discussion of neurosurgical management principles.
Main Results:
- The classic triad of symptoms is present in only one-fifth of patients.
- Non-specific symptoms like raised intracranial pressure are more common.
- Diffusion-weighted MRI aids in differentiating brain abscesses from malignant tumors.
Conclusions:
- Early diagnosis and management of brain abscesses in a neurosurgical center are crucial.
- Distinguishing brain abscesses from other pathologies is vital due to different management strategies.
- Advanced imaging techniques like MRI are essential for accurate diagnosis and patient care.
More Related Videos
09:58A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
Published on: May 6, 2016
10:38Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
Related Concept Videos
The Blood-brain Barrier
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
Anatomy of the Brain: Ventricles
Brain Imaging
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Veins of Head and Neck
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...