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Updated: Dec 10, 2025
07:24
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
Published on: July 9, 2021
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Exploring Non-Coding RNAs in RNAcentral
Blake A Sweeney1, Arina A Tagmazian1,2, Carlos E Ribas1
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Current Protocols in Bioinformatics
|August 27, 2020
Summary
RNAcentral is a unified database for non-coding RNAs (ncRNAs), integrating data from over 40 resources. It offers multiple access methods, including web APIs and a Galaxy workflow for RNA-seq analysis.
Area of Science:
- Molecular Biology
- Bioinformatics
- Genomics
Background:
- Non-coding RNAs (ncRNAs) are crucial for cellular functions across all life forms.
- Data on ncRNAs is fragmented across numerous specialized databases.
- Understanding ncRNA function requires integrated access to diverse annotations.
Purpose of the Study:
- To introduce RNAcentral as a comprehensive, unified database for non-coding RNA sequences and annotations.
- To detail various methods for accessing and utilizing RNAcentral data.
- To demonstrate the application of RNAcentral in RNA sequencing (RNA-seq) analysis.
Main Methods:
- Website-based searching and data retrieval.
- Programmatic access via web APIs.
- Direct access to a public PostgreSQL database.
- Integration with Galaxy for RNA-seq differential expression analysis.
Main Results:
- RNAcentral consolidates annotations from over 40 contributing databases.
- Provides user-friendly web interfaces for data exploration.
- Offers robust programmatic access for automated data retrieval and analysis.
- Enables advanced analysis, such as differential gene expression, using RNA-seq data.
Conclusions:
- RNAcentral serves as a central hub for non-coding RNA information.
- Facilitates deeper insights into ncRNA function through integrated data access.
- Empowers researchers with versatile tools for ncRNA data analysis.
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